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Moreover, the researchers found out the ACKR3 receptor at higher concentrations in key brain regions that happen to be also significant opioid exercise facilities.
When the opiate receptor relies on G protein coupling for sign transduction, this receptor was located to utilize arrestin activa
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These success, together with a previous report showing that a small-molecule ACKR3 agonist CCX771 reveals anxiolytic-like actions in mice,two assist the strategy of targeting ACKR3 as a novel strategy to modulate the opioid procedure, which could open up new therapeutic avenues for opioid-linked